Procalcitonin and Adrenomedullin in Infectious Diseases

Calcitonin (CT) and adrenomedullin (ADM) are members of the CT family. Procalcitonin (PCT) is a prohormone CT. Elevations in serum PCT ADM levels associated with severe sepsis coronavirus disease 2019 (COVID-19). enhances mortality it binds to CGRP receptor, which heterodimer receptor-like receptor activity-modifying protein 1. The N-terminal truncated form PCT, PCT3-116, produced by cleavage dipeptidyl peptidase 4 (DPP-4) main during sepsis, inducing microvascular permeability. Mid-regional pro-adrenomedullin (MR-proADM) used instead as biological indicator because rapidly degraded, MR-proADM released at same rate ADM. reduces endothelial permeability promotes stability. Endothelial dysfunction responsible for multiple organ failure COVID-19 patients. Therefore, may be an important molecule improving severity COVID-19. This review focuses on current knowledge